In the northeastern U.S., people suddenly begin committing mass suicide. First they become disoriented, then stop moving, and finally find the quickest way to kill themselves. The pandemic begins in parks, and quickly spreads to nearby population centers. It is initially believed to be a bioterrorist attack, but this is ruled out as the events increase in frequency.
Elliot Moore (Mark Wahlberg) is a science teacher in Philadelphia. After the school is informed of the pandemic, he decides to leave the city with his wife, Alma Moore (Zooey Deschanel), and his fellow math teacher, Julian (John Leguizamo), who is also bringing his eight-year-old daughter, Jess (Ashlyn Sanchez). The train soon stops at a small town in western Pennsylvania; train services are discontinued after the crew loses contact with "everyone." Julian finds out that the "attacks" have hit Princeton, where his wife is currently headed, and leaves Jess with Elliot while he hitches a ride in an attempt to retrieve her. However, it has already been hit by the pandemic.....
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